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Senior Research Associate/Associate Scientist, Biomolecular Interaction

BigHat Biosciences

BigHat Biosciences

San Mateo, CA, USA
USD 100k-120k / year
Posted on May 3, 2025
The Role: BigHat Biosciences is seeking a self-motivated individual for a Senior Research Associate or Associate Scientist role* in the Protein Sciences team to develop label-free assays for characterizing antigen-antibody interactions. Your position will interface regularly with the Discovery Medicine, Production, and Automation teams to support all aspects of biophysical characterization of antigen-antibody binding in a fast-paced and multidisciplinary environment.

*At BigHat we believe in titles that commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.
Department
Lab Science
Employment Type
Full Time
Location
San Mateo, CA
Workplace type
Onsite
Reporting To

This role's hiring manager:
Jessie Peh

Key Responsibilities

  • Design, develop, and perform kinetic experiments to study antigen-antibody interactions using label-free techniques
  • Troubleshooting of kinetic experiments on both BLI and SPR platforms
  • Perform epitope binning and quantitation experiments
  • Develop and onboard kinetic assays for screening antibodies in a high-throughput manner
  • Write and transfer standard operating protocols (SOPs) for use on the Milliner Platform
  • Keep a detailed record of all experiments using BigHat’s documentation tools, and clearly communicate results and challenges
  • Present experimental plans and results during regular meetings with manager and science teams

Skills Knowledge and Expertise

  • B.S. with 5+ or M.S. with 3+ years of work experience in industry
  • Experience using label-free biophysical techniques to study antigen-antibody interactions
  • Extensive experience in developing, executing, troubleshooting SPR and BLI experiments for kinetics, quantitation, and epitope binning
  • Good record keeping skills using LIMS and electronic notebooks
  • Excited to work with diverse, cross functional teams to onboard new assays and disseminate results
  • Prior experience with automation is preferred

Compensation

For SRA: $[100 - 120]K
For Associate Scientist: $[120 - 140]K

About BigHat Biosciences

BigHat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology.

BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these design capabilities to develop new generations of safer and more effective treatments for patients suffering from today’s most challenging diseases.
BigHat is a Series B biotech outside San Francisco with a team-oriented, inclusive, and family-friendly culture. Our broad pipeline of wholly-owned and partnered therapeutic programs span many disparate indications with high unmet need, such as cancer, inflammation, and infectious disease. BigHat has raised >$100M from top investors, including Section 32, a16z, and 8VC.

Our Hiring Process

Stage 1:

Applied

Stage 2:

Initial Conversation | Head of Talent

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