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Director - Protein Biochemistry

Think Bioscience

Think Bioscience

Boulder, CO, USA
Posted on Wednesday, October 26, 2022

Think Bioscience

Director - Protein Biochemistry

Boulder, ColoradoFull-time
About the Job
Director of Biochemistry

Company Description:
Think Bioscience is a fully integrated drug discovery company dedicated to developing life-saving medicines. Our creative, multidisciplinary team combines applied microbiology, enzymology, multi-dimensional screens, and data science to drug “undruggable” targets. Our best-in-class platform delivers novel scaffolds and pockets that accelerate drug development. 
 
We are passionate about using innovative science to improve the lives of patients. Our team is our core—the key to our success. If you share our passion, let’s work together. 
 
Job Description:
We are seeking an experienced Director of Biochemistry to lead our research efforts in enzymology, biophysics, and structural biology, broadly defined. As the leader of our biochemistry research group, you will play a critical role in driving the discovery and optimization of novel small-molecule drug candidates. Your expertise in enzyme mechanisms, biochemical kinetics, and advanced biophysical methods will be instrumental in shaping our internal pipeline and advancing small molecule drug discovery programs to the clinic.
 
Responsibilities:
  • Design and implement robust enzyme assays to characterize small-molecule modulators, and develop screening workflows to support the pipeline team  
  • Oversee the structural biology efforts, including X-ray crystallography, NMR spectroscopy, or cryo-electron microscopy (cryo-EM), to determine high-resolution structures of target proteins and their complexes with small molecules. 
  • Investigate and validate protein-small molecule interactions using advanced biophysical methods and biochemical assays to support lead selection and optimization.
  • Oversee the expression and purification of recombinant proteins, ensuring high quality and yields for biochemical analyses and structural biology
  • Collaborate with medicinal chemists and computational biologists to optimize small-molecule leads based on the understanding of protein structure-activity relationships.
  • Apply high-throughput screening approaches to identify small-molecule modulators
  • Analyze and interpret experimental data, present findings to the leadership team, and make data-driven decisions to advance drug discovery projects. 
  • Lead and mentor a team of scientists, providing scientific guidance, fostering collaboration, and promoting a culture of innovation and scientific rigor.
  • Collaborate with cross-functional teams, including computational biology, pharmacology, and drug metabolism and pharmacokinetics (DMPK), to drive integrated drug discovery projects.
 
Qualifications:
  • Ph.D. with at least 8 years of relevant industry experience or a B.S. or M.S. and at least 15 years of experience
  • Successful track record driving drug discovery programs forward by leading protein biochemistry, biophysics, protein mechanism of action, and structure/function studies
  • Deep understanding of the structure/function and enzymology of phosphatases and kinases
  • Experience leveraging structural biology to enable small molecule discovery programs
  • Experience leading and coordinating research teams (external academic, CRO, internal) working concurrently on multiple projects
  • Adaptability and flexibility to work in a dynamic startup environment
 
What We Offer:
Collaborative environment for innovative science and a mission-drive company
Opportunity for technical expansion and professional growth
Ability to influence key decisions in a fast-growing startup
Competitive compensation and benefits package, including a salary range of $140,000 - $200,000 per year (title and salary commensurate with experience) 

Think Bioscience is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization or any other non-merit factors.