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Head of Clinical Operations \n
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Head of Clinical Operations \n
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Position Summary
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The Head of Clinical Operations will be responsible for the operational management of early phase clinical trial(s), starting with a Phase 1/2a trial for a peanut allergy therapeutic, and for the delivery of operational activities as defined in the trial outline/protocol and clinical development plan, according to the agreed quality, budget and timelines.
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The position requires hands on work and routine interaction with key internal and external stakeholders, communicating clinical status, escalating issues, and troubleshooting routine inquiries.
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Responsibilities
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\nLead the operational management of the trial - build its operational strategy and be in charge of study execution
\nProvide Clinical Operations expertise and leadership in the evaluation, selection, and management of Global Contract Research Organizations (CROs) and other external vendors to ensure successful First in Human clinical trial implementation and execution
\nProactively manage CROs and other vendors in all aspects of study progress from planning to close-out
\nLead study start-up: Identify potential study sites, site selection and facilitate the development of clinical trial agreements and other relevant documents
\nLead the development, approval, execution and maintenance of all study operational plans (i.e. trial risk management plan, communication plan, monitoring plan, data plan, etc.)
\nCollaborate cross functionally with the program clinical development functions (internal and external stakeholders) to deliver the trial according to plan and in the highest quality standards
\nOversee, manage, and ensure clinical trials are executed per key metrics (timelines, budget, operational and quality standards [ICH/GCP/SOPs])
\nManage and ensure the execution of the logistical plan for the trial (trial materials supply, labeling and packaging, etc.)
\nContribute and/or author the creation and finalization of key trial documentation: Protocols, Informed consent Forms, Investigator Brochures, Pharmacy Manual, Laboratory Manual, Manual of Operations, Clinical Study Report, etc.
\nContribute to global & local regulatory submissions (FDA, EMA, IMoH and other governing regulatory bodies)
\nLiaise with clinical site staff and Investigators as appropriate to ensure optimal sponsor-site relationships
\nProvide ongoing clinical trial financial reporting and forecasting
\nDevelop, review and approve Clinical Quality Documents
\nWillingness to work on the strategy level and also work hands-on
\nWillingness to work on the strategist level and also work hands-on
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Experience
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\nMinimum 10 years clinical trial operations experience in pharmaceutical, CRO, or healthcare industry - required
\nBachelor degree in a related scientific field - required; M.Sc. / Ph.D or M.D in relevant disciplines - advantage
\nExperience with study start-up, timeline planning and management and financial management of clinical trials including vendor oversight - required
\nPrevious experience in management of domestic (Israel) as well as international clinical trials - preferred
\nThorough understanding of clinical research principles and process
\nStrong knowledge of GCP and regulatory requirements
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Skills
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\nExcellent organizational and time-management skills
\nStrong interpersonal skills
\nEffective verbal and written communication skills including presentation skills, in English and in Hebrew
\nTeam player and able to work independently
\nAbility to work well under pressure and with tight schedules
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Position location: Rehovot, Israel + Overseas travel (as needed)
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Apply via: jobs@ukko.us or Apply now
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Head of Clinical Operations Operations
Palo Alto, CA, USA · Tel Aviv-Yafo, Israel
Posted on Tuesday, August 8, 2023
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